Impact of Age, Menopause, and Obesity on Oxylipins Linked to Vascular Health

Objective: Cardiovascular disease, a major cause of mortality and morbidity, exhibits sexual dimorphism since the onset cardiovascular disease occurs later in women than men. The loss cardioprotection older may be due to an increase arterial stiffness after menopause. Free fatty acid metabolites polyunsaturated acids, called oxylipins, are known impact vessel function responsible for vascular benefits acids. objectives this study were compare plasma oxylipin profiles young females (20–55 years), (55 + ), males ) identify associations between oxylipins risk factors, such as obesity stiffness. Approach Results: We quantified by high-performance liquid chromatography–tandem mass spectrometry archived samples taken from completed clinical trials. identified 3 12-lipoxygenase products, 12-hydroxy-eicosatetraenoic acid, 12-hydroxy-eicosapentaenoic 14-hydroxy-docosahexaenoic that present at high levels compared with males. These also decreased displayed robust negative assessed brachial-ankle pulse wave velocity. According multiple linear regression modeling, these maintained even correcting body index category combined either age, menopausal status, or estradiol levels. Using discriminant analysis, combination effectively distinguished participants according both velocity group age. Conclusions: Higher concentrations associated lower premenopausal important contributing factor sex differences disease. Registration: URL: https://www.clinicaltrials.gov ; Unique identifiers: NCT01661543, NCT01562171, NCT01890330, NCT02571114 NCT02317588.